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dc.contributor.authorPaulsen, Katrine Mørk
dc.contributor.authorDas Neves, Carlos G
dc.contributor.authorGranquist, Erik Georg
dc.contributor.authorMadslien, Knut Ivar Engesæter
dc.contributor.authorStuen, Snorre
dc.contributor.authorPedersen, Benedikte Nevjen
dc.contributor.authorVikse, Rose
dc.contributor.authorRocchi, Mara
dc.contributor.authorLaming, Eleanor
dc.contributor.authorStiasny, Karin
dc.contributor.authorAndreassen, Åshild Kristine
dc.date.accessioned2020-06-03T07:50:27Z
dc.date.available2020-06-03T07:50:27Z
dc.date.created2020-01-13T15:10:08Z
dc.date.issued2019
dc.identifier.citationZoonoses and Public Health. 2019, .
dc.identifier.issn1863-1959
dc.identifier.urihttps://hdl.handle.net/11250/2656272
dc.description.abstractTick‐borne encephalitis virus (TBEV) is the causative agent of tick‐borne encephalitis (TBE). TBEV is one of the most important neurological pathogens transmitted by tick bites in Europe. The objectives of this study were to investigate the seroprevalence of TBE antibodies in cervids in Norway and the possible emergence of new foci, and furthermore to evaluate if cervids can function as sentinel animals for the distribution of TBEV in the country. Serum samples from 286 moose, 148 roe deer, 140 red deer and 83 reindeer from all over Norway were collected and screened for TBE immunoglobulin G (IgG) antibodies with a modified commercial enzyme‐linked immunosorbent assay (ELISA) and confirmed by TBEV serum neutralisation test (SNT). The overall seroprevalence against the TBEV complex in the cervid specimens from Norway was 4.6%. The highest number of seropositive cervids was found in south‐eastern Norway, but seropositive cervids were also detected in southern‐ and central Norway. Antibodies against TBEV detected by SNT were present in 9.4% of the moose samples, 1.4% in red deer, 0.7% in roe deer, and nil in reindeer. The majority of the positive samples in our study originated from areas where human cases of TBE have been reported in Norway. The study is the first comprehensive screening of cervid species in Norway for antibodies to TBEV, and shows that cervids are useful sentinel animals to indicate TBEV occurrence, as supplement to studies in ticks. Furthermore, the results indicate that TBEV might be spreading northwards in Norway. This information may be of relevance for public health considerations and supports previous findings of TBEV in ticks in Norway.
dc.language.isoeng
dc.titleCervids as sentinel-species for tick-borne encephalitis virus in Norway - A serological study
dc.typePeer reviewed
dc.typeJournal article
dc.description.versionpublishedVersion
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode2
dc.identifier.doi10.1111/zph.12675
dc.identifier.cristin1771672
dc.source.journalZoonoses and Public Health
dc.source.pagenumber10
dc.relation.projectInterreg: 167226
dc.relation.projectInterreg: 20200422
dc.relation.projectHelsedepartementet: B1412


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